Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences
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چکیده
منابع مشابه
Pediatric Orbital Primitive Neuroectodermal Tumors.
PURPOSE To present the clinical, radiological, histopathological, immunohistochemical features and the follow-up of orbital primitive neuroectodermal tumors (PNETs) in pediatric patients along with a review of the literature. METHODS A retrospective analysis of all diagnosed cases of orbital PNET was done. Patients' ophthalmic findings, imaging, immunohistochemistry, metastatic work-up, treat...
متن کاملSupratentorial primitive neuroectodermal tumors in young children.
TO THE EDITOR: In the April issue of the Journal of Clinical Oncology, Timmermann et al suggest that radiotherapy plays a major role in the treatment of young children with supratentorial primitive neuroectodermal tumors (stPNET) and conclude that a delay in irradiation may compromise survival. Although stPNET are undoubtedly aggressive brain tumors and results of treatments are still disappoin...
متن کاملComputed tomography of primitive neuroectodermal tumors.
The primitive neuroectodermal tumor is a neoplasm of young individuals that occurs predominantly in the supratentorial compartment. It appears on computed tomography as a bulky mass, often with calcification with predominantly homogeneous enhancement but on occasion with cystic or necrotic areas. Cerebrospinal fluid seeding was observed in more than half the cases in our series. The patients ha...
متن کاملMutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.
Germ-line and somatic mutations of the hSNF5/INI1 gene have been reported in atypical teratoid/rhabdoid tumors (AT/RTs) of the brain, consistent with its role as a tumor suppressor gene. In the present study, we determined the frequency of deletions and mutations of INI1 in 52 children whose original diagnosis was medulloblastoma (MB) or primitive neuroectodermal tumor (PNET) of the central ner...
متن کاملPrognostic Significance of Chromosome l7p Deletions in Childhood Primitive Neuroectodermal Tumors (Medulloblastomas) of the Central Nervous System’
Deletions in the short arm of chromosome 17 (Yip) are the most common genetic abnormality in primitive neuroectodermal tumors of the posterior fossa/medulloblastoma (PNETIMb). The biological consequences of these deletions are not known for children with PNETIMb; however, the presence of a tumor suppressor gene located in l’lp, distinct from p53, has been implicated in tumorigenesis. Two recent...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2002
ISSN: 1522-8517,0000-0000
DOI: 10.1215/s1522851701000606